RT Journal Article SR Electronic T1 Serial high-sensitivity troponin measurements for the rapid exclusion of acute myocardial infarction in low-risk patients JF Emergency Medicine Journal JO Emerg Med J FD BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine SP 593 OP 594 DO 10.1136/emermed-2012-201574 VO 30 IS 7 A1 Charlotte Dawson A1 Jonathan R Benger A1 Graham Bayly YR 2013 UL http://emj.bmj.com/content/30/7/593.abstract AB High-sensitivity troponin assays facilitate the rapid exclusion of acute myocardial infarction (AMI). However, elevated results are also seen in other conditions causing myocardial injury. Serial measurements increase the specificity for AMI, helping to rapidly identify patients for whom revascularisation may be appropriate. In this study, we explore a strategy for rapidly excluding AMI in symptomatic patients using serial high-sensitivity troponin measurements. Main findings: (1) all patients presenting more than 3 h after symptom onset with a negative result had a second negative result; (2) AMI was excluded in all patients with two results falling below the lower limit of detection of a standard troponin assay by 8 h post-symptom onset.