PT - JOURNAL ARTICLE AU - Sharon Ann Swain AU - Graham Stiff TI - Issues and challenges for research in major trauma AID - 10.1136/emermed-2017-207082 DP - 2018 Apr 01 TA - Emergency Medicine Journal PG - 267--269 VI - 35 IP - 4 4099 - http://emj.bmj.com/content/35/4/267.short 4100 - http://emj.bmj.com/content/35/4/267.full SO - Emerg Med J2018 Apr 01; 35 AB - The starting point for evidence-based guidelines is the systematic review and critical appraisal of the relevant literature. This review highlights the risk of bias identified while critically appraising the evidence to inform the National Institute of Health and Care Excellence guideline on the assessment and initial management of major trauma.