TY - JOUR T1 - Issues and challenges for research in major trauma JF - Emergency Medicine Journal JO - Emerg Med J SP - 267 LP - 269 DO - 10.1136/emermed-2017-207082 VL - 35 IS - 4 AU - Sharon Ann Swain AU - Graham Stiff Y1 - 2018/04/01 UR - http://emj.bmj.com/content/35/4/267.abstract N2 - The starting point for evidence-based guidelines is the systematic review and critical appraisal of the relevant literature. This review highlights the risk of bias identified while critically appraising the evidence to inform the National Institute of Health and Care Excellence guideline on the assessment and initial management of major trauma. ER -