RT Journal Article
SR Electronic
T1 Higher clinical acuity and 7-day hospital mortality in non-COVID-19 acute medical admissions: prospective observational study
JF Emergency Medicine Journal
JO Emerg Med J
FD BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine
SP emermed-2020-210030
DO 10.1136/emermed-2020-210030
A1 Marcus J Lyall
A1 Nazir I Lone
YR 2021
UL http://emj.bmj.com/content/early/2021/03/02/emermed-2020-210030.abstract
AB Objectives To understand the effect of COVID-19 lockdown measures on severity of illness and mortality in non-COVID-19 acute medical admissions.Design A prospective observational study.Setting 3 large acute medical receiving units in NHS Lothian, Scotland.Participants Non-COVID-19 acute admissions (n=1682) were examined over the first 31 days after the implementation of the COVID-19 lockdown policy in the UK on 23 March 2019. Patients admitted over a matched interval in the previous 5 years were used as a comparator cohort (n=14 954).Main outcome measures Patient demography, biochemical markers of clinical acuity and 7-day hospital inpatient mortality.Results Non-COVID-19 acute medical admissions reduced by 44.9% across all three sites in comparison with the mean of the preceding 5 years (p<0.001). Patients arriving during this period were more likely to be male, of younger age and to arrive by emergency ambulance transport. Non-COVID-19 admissions during lockdown had a greater incidence of acute kidney injury, lactic acidaemia and an increased risk of hospital death within 7 days (4.2% vs 2.5%), which persisted after adjustment for confounders (OR 1.87, 95% CI 1.43 to 2.41, p<0.001).Conclusions These data demonstrate a significant reduction in non-COVID-19 acute medical admissions during the early weeks of lockdown. Patients admitted during this period were of higher clinical acuity with a higher incidence of early inpatient mortality.