TY - JOUR T1 - Hyperbaric oxygen as an adjuvant treatment for patients with COVID-19 severe hypoxaemia: a randomised controlled trial JF - Emergency Medicine Journal JO - Emerg Med J DO - 10.1136/emermed-2021-211253 SP - emermed-2021-211253 AU - Mariana Cannellotto AU - Mariano Duarte AU - Guillermo Keller AU - Ramiro Larrea AU - Eleonora Cunto AU - Viviana Chediack AU - Mariela Mansur AU - Daniela M Brito AU - Elizabeth García AU - Héctor E Di Salvo AU - Fabrizio Verdini AU - Cecilia Domínguez AU - Liliana Jorda-Vargas AU - Javier Roberti AU - Guillermo Di Girolamo AU - Esteban Estrada Y1 - 2021/12/11 UR - http://emj.bmj.com/content/early/2021/12/12/emermed-2021-211253.abstract N2 - Background Hyperbaric oxygen (HBO2) therapy has been proposed to treat hypoxaemia and reduce inflammation in COVID-19. Our objective was to analyse safety and efficacy of HBO2 in treatment of hypoxaemia in patients with COVID-19 and evaluate time to hypoxaemia correction.Methods This was a multicentre, open-label randomised controlled trial conducted in Buenos Aires, Argentina, between July and November 2020. Patients with COVID-19 and severe hypoxaemia (SpO2 ≤90% despite oxygen supplementation) were assigned to receive either HBO2 treatment or the standard treatment for respiratory symptoms for 7 days. HBO2 treatment was planned for ≥5 sessions (1 /day) for 90 min at 1.45 atmosphere absolute (ATA). Outcomes were time to normalise oxygen requirement to SpO2 ≥93%, need for mechanical respiratory assistance, development of acute respiratory distress syndrome and mortality within 30 days. A sample size of 80 patients was estimated, with a planned interim analysis after determining outcomes on 50% of patients.Results The trial was stopped after the interim analysis. 40 patients were randomised, 20 in each group, age was 55.2±9.2 years. At admission, frequent symptoms were dyspnoea, fever and odynophagia; SpO2 was 85.1%±4.3% for the whole group. Patients in the treatment group received an average of 6.2±1.2 HBO2 sessions. Time to correct hypoxaemia was shorter in treatment group versus control group; median 3 days (IQR 1.0–4.5) versus median 9 days (IQR 5.5–12.5), respectively (p<0.010). OR for recovery from hypoxaemia in the HBO2 group at day 3 compared with the control group was 23.2 (95% CI 1.6 to 329.6; p=0.001) Treatment had no statistically significant effect on acute respiratory distress syndrome, mechanical ventilation or death within 30 days after admission.Conclusion Our findings support the safety and efficacy of HBO2 in the treatment of COVID-19 and severe hypoxaemia.Trial registration number NCT04477954.Data are available on reasonable request. Additional information available on request to authors. ER -