Table 5
Author, date and countryPatient groupStudy levelOutcomesKey resultsStudy weaknesses
Brandjes D, et al, 1997, Holland1194 consecutive patients with a first episode of proximal DVT (proved on venogram).PRCTIncidence of PTSMild to moderate PTS occurred in 19 patients in the stocking group and in 46 patients in the control group (p≤0.001)Due to the non blinded design, potential bias in the assessment of post-thrombotic syndrome
Custom fitted graduated compression stockings (96), v no stockings (98).PTS was assessed using clinical characteristics and leg measurements11 patients in the stocking group developed severe PTS compared with 23 in the control group (p≤0.001)Lack of an accepted definition of PTS
Assessment every 3 months for 2 years, and thereafter every 6 months for at least 5 years.