| Brandjes D, et al, 1997, Holland1 | 194 consecutive patients with a first episode of proximal DVT (proved on venogram). | PRCT | Incidence of PTS | Mild to moderate PTS occurred in 19 patients in the stocking group and in 46 patients in the control group (p≤0.001) | Due to the non blinded design, potential bias in the assessment of post-thrombotic syndrome |
| Custom fitted graduated compression stockings (96), v no stockings (98). | | PTS was assessed using clinical characteristics and leg measurements | 11 patients in the stocking group developed severe PTS compared with 23 in the control group (p≤0.001) | Lack of an accepted definition of PTS |
| Assessment every 3 months for 2 years, and thereafter every 6 months for at least 5 years. | | | | |