Table 1
Author, date and countryPatient groupStudy type (level of evidence)OutcomesKey resultsStudy weaknesses
Leppik et al, 1983, USA78 adult patients with status epilepticus.PRCTClinical control of seizure activity:Lorazepam 89% within 2 dosesSmall numbers
iv Lorazepam (4 mg) v iv diazepam (10 mg)v diazepam 76% within 2 dosesMany different types of seizure activity
Treiman et al, 1998, USA384 patients with generalised convulsions from 570 patients with status epilepticus.PRCTStopping all motor seizure activity / EEG activity in <20 minutes.55.8% v 64.9% v 58.2% v 43.6%Some patients were treated prior to inclusion in trial.
iv diazepam (0.15 mg/kg) plus phenytoin (0.1 mg/kg) vIn an intention to treat analysis the differences between treatment groups were not significant (p=0.12).No long term follow up of patients.
iv lorazepam (0.1 mg/kg) v
iv phenobarbitone (15 mg/kg) v
iv phenytoin (18 mg/kg)