Author, date and country | Patient group | Study type (level of evidence) | Outcomes | Key results | Study weaknesses |
---|---|---|---|---|---|
Gomez HF et al, 1997, USA | 11 healthy adult volunteers | Controlled, prospective crossover study | Maximum serum iron concentration: | Healthy volunteers | |
- iron only | 150 μg/dl 36 | Strict exclusion criteria | |||
- iron plus activated charcoal (AC) | 94 μg/dl 23 | Physiological doses of iron rather than toxic doses | |||
- iron plus AC plus desferrioxamine | 37 μg/dl 13 | ||||
(p 0.0017) | |||||
Time to maximum serum iron concentration: | |||||
- iron only | 3.5 h 0.3 | ||||
- iron plus AC | 3.6 h 0.5 | ||||
- iron plus AC plus desferrioxamine | 3.0 h 1.0 |