Drug treatment in eclampsia 4
| Drug | Dose | Onset | Side effects |
|---|---|---|---|
| iv=intravenous. | |||
| Seizure control | |||
| Diazepam | 5–10 mg slow iv bolus | ||
| or | |||
| Lorazepam | 2–4 mg slow iv bolus | ||
| Magnesium sulphate | 4–6 g slow iv bolus over 5 minutes then 1–2 g/h iv infusion | Loss of patellar reflexes | |
| Drowsiness | |||
| Slurring of speech | |||
| Flushing | |||
| Muscle weakness | |||
| Respiratory depression | |||
| Blood pressure control | |||
| Hydralazine | 5 mg slow iv bolus every 20–30 min | 10 min | Headache, tremor, nausea, vomiting, tachycardia |
| or | |||
| Labetalol | 10 mg slow iv bolus doubling every 10– 20 min to max 300 mg total or 1–2 mg/min iv infusion | 5–10 min | Bradycardia (fetal), maternal flushing, nausea |
| Fluids | |||
| Crystalloid | 1–2 ml/kg/h with monitoring of urine output | ||