Table 3
Author, date and countryPatient groupStudy type (level of evidence)OutcomesKey resultsStudy weaknesses
Larsson K and Sollevi A, 1988, Sweden5 well subjects with a previous diagnosis of asthma.Crossover placebo trialHRNo significant differenceChildren only
BPNo significant differenceRetrospective chart review
Increasing doses of adenosine v placeboPulmonary functionNo significant difference
Losek JD et al, 1999, USA82 patients aged 18 yrs or less who received iv adenosine in the ED for the treatment of SVT.SurveySuccessful cardioversion72% cardioversion success rateDose of adenosine very different to that used clinically
Adverse effects22 adverse patient events, no bronchospasm but 2 complaints of “dyspnoea” in non-asthmatic patientsSubjects well, and in normal sinus rhythm
13 had documented evidence of asthma