Author, date and country | Patient group | Study type (level of evidence) | Outcomes | Key results | Study weaknesses |
---|---|---|---|---|---|
ISIS-2, 1988, multinational | 17 187 patients within 24 hours of suspected MI. | PRCT | Overall vascular mortality | 4% relative risk reduction (0–4 h v 5–12 h v 13–24 h, p=NS) | Not the primary aim of the study, so very hard to extract data. |
iv streptokinase or aspirin or both or neither | Odds of death at 5 weeks v placebo | ||||
Subgroup analysis mortality v time of aspirin administration from onset of symptoms at 0–4 h, 5–12 h, 5–24 h | 0–4 h | 0.75 (SD=0.07) | |||
5–12 h | 0.79 (SD=0.07) | ||||
13–24 h | 0.79 (SD=0.12) |