Table 3
Author, date and countryPatient groupStudy type (level of evidence)OutcomesKey resultsStudy weaknesses
Benson WH et al, 1993, USAUnimmunised mice(Prospective) Experimental animal modelIncidence of clinical tetanus following:Animal model
Animal model surgically injecting live C tetani or tetanus toxin into mice corneaC tetani organisms and toxin used pure – not representative of usual clinical mixed flora
- corneal abrasion0/9
- corneal penetration0/9
- corneal perforation10/27
Incidence in immunised mice0/42