| Author, date and country | Patient group | Study type (level of evidence) | Outcomes | Key results | Study weaknesses |
|---|---|---|---|---|---|
| Benson WH et al, 1993, USA | Unimmunised mice | (Prospective) Experimental animal model | Incidence of clinical tetanus following: | Animal model | |
| Animal model surgically injecting live C tetani or tetanus toxin into mice cornea | C tetani organisms and toxin used pure – not representative of usual clinical mixed flora | ||||
| - corneal abrasion | 0/9 | ||||
| - corneal penetration | 0/9 | ||||
| - corneal perforation | 10/27 | ||||
| Incidence in immunised mice | 0/42 |