Table 2
Author, date and countryPatient groupStudy type (level of evidence)OutcomesKey resultsStudy weaknesses
Henderson RD et al, 1978, Canada100 patients with typical reflux pain. 43 with atypical pain and investigations showing oesophageal disease and normal coronary arteriesClinical trialRelief of pain with antacids95% relief in typical reflux group. 18% atypical pain groupSmall numbers
No blinding
Statistical significance not assessed
Antacid type/dose not described
Simpson FG et al, 1984, UK46 patients with proven MISurveyPain felt to be indigestion21/46 (45%)Small numbers
Relief of pain in those that had taken antacids5/17 (29%)Statistical significance not assessed