| Henderson RD et al, 1978, Canada | 100 patients with typical reflux pain. 43 with atypical pain and investigations showing oesophageal disease and normal coronary arteries | Clinical trial | Relief of pain with antacids | 95% relief in typical reflux group. 18% atypical pain group | Small numbers |
| | | | | No blinding |
| | | | | Statistical significance not assessed |
| | | | | Antacid type/dose not described |
| Simpson FG et al, 1984, UK | 46 patients with proven MI | Survey | Pain felt to be indigestion | 21/46 (45%) | Small numbers |
| | | Relief of pain in those that had taken antacids | 5/17 (29%) | Statistical significance not assessed |