| Adams RA, et al, 1980, UK | 392 patients with paracetamol overdose of whom 120 took paracetamol alone | Observational | Vomiting | 11.7% vomited before the onset of antidote therapy | Does not report the incidence of vomiting in the paracetamol alone group |
| | | | | Cannot exclude the confounding influence of co-ingestants (eg dextropropoxyphene in 112 patients) |
| Scharman EJ, 1998, USA | 1009 adult patients with a paracetamol ovedose, who were reported to a poisons centre. | Observational | Vomiting | 12.5% vomited (61% were in the toxic range and 41% had taken co-ingestants) | No attempt to assess the proportion of patients in the non-vomiting group who had taken co-ingestants or who were in the toxic range |
| | | Antiemetic used and its effectiveness | 33% failed first line antiemetic therapy and were given ondansetron: of these 16% failed (ie 4% required IV antidote) | |