Table 1

Phases of colchicine toxicity

PhaseSymptoms
I 0–24 hoursNausea, vomiting, diarrhoea, abdominal pain, and anorexia
Electrolyte imbalance and hypovolaemia
Peripheral leucocytosis
II 2–7 daysBone marrow hypoplasia, profound leucopenia, and thrombocytopenia
Cardiac arrythmias and cardiovascular collapse
Respiratory distress, hypoxia, pulmonary oedema, and ARDS
Oliguric renal failure
Rhabdomyolysis
Electrolyte derangements
Metabolic acidosis
Mental state changes
Seizures
Peripheral neuropathy and ascending paralysis
III 7th day onwardsRebound leucocytosis
Transient alopecia