Table 2
Author, date and countryPatient groupStudy type (level of evidence)OutcomesKey resultsStudy weaknesses
Brodovsky SC et al, 2000, Australia121 patients with 177 alkali burnt eyes over 11 years.Retrospective clinical comparisonTime to re-epithelialisationDelay in grade 2 burns. Trend for longer in 1, shorter in 3 and no difference in 4Uncontrolled. Very few conservatively treated patients
Standard alkali protocol (antibiotics, intensive topical corticosteroids, ascorbate, citrate and antibiotics) v conservative protocal (antibiotics, short course of corticosteroids)Final visual acuityBetter in grade 3 burns. No difference in 1, 2, and 4Conclude that ascorbate and citrate are the effective agent for grade 3 burns without considering the effect of intensive corticosteroid alone