| Vale JA, 1981, UK | 158 patients with paracetamol overedose. Mean age: 26 y. 1:2 M, F ratio | Prospective observational | Liver damage: | NSD | No randomisation |
| | | Methionine within 10 h (n=96) | 7% | Small study |
| High risk patients defined as paracetamol level: >300 mg/l at 4 h. | | IV n-acetylcysteine within 10 h (n=62) | 2% | 2 of 7 vomited the first dose |
| | | In high risk patients methionine. within 10 h (n=43) | 14% | |
| | | In high risk patients IV n-acetylcysteine. within 10 h (n=33) | 3% | |
| Prescott LF, 1981, UK | 104 patients with paracetamol overdose. Mean age 33 y 1:1.5 M, F ratio | Prospective observational | Liver damage: | NSD | No randomisation |
| | | Methionine. Within 10 h, (n=42) 57% of them were high risk | 7% | Small study |
| High risk patients defined as paracetamol level: >300 mg/l at 4 h | | IV n acetyl cysteine within 10 h (n=62) 33of 62 (53%) of them were high risk | 2% | |