Estimates of two eligible studies of diagnostic accuracy of serum prolactin concentration (three times the baseline within one hour of collapse) in detecting GTCS from pseudoseizure
| Sensitivity | Specificity | ||||
|---|---|---|---|---|---|
| Study | (true positives + false negatives) | Sensitivity | Study | (false positives + true negatives) | Specificity |
| 3 Trimble 1978 | 4/8 | 50% | 3 Trimble 1978 | 5/6 | 83% |
| 13 Laxer 1985 | 23/31 | 74% | 13 Laxer 1985 | 19/20 | 95% |
| Pooled estimate of SN = 0.62 (95% CI (0.40 to 0.83)) | Pooled estimate of SP = 0.89 (95% CI (0.60 to 0.98)) | ||||
| Pooled +ve likelihood ratio = 8.92 (1.31 to 60.91) (Lr+ve >5, strong diagnostic evidence) | Pooled −ve likelihood ratio = 0.44 (0.22 to 0.91) (Lr−ve <0.1 = convincing evidence) | ||||
| Post-test probability = 93% chance of a GTCS if test positive (RULE IN DIAGNOSIS of GTCS) | Post-test probability = 39% chance of GTCS event if test negative (RULE OUT DIAGNOSIS of GTCS) | ||||