Table 1
Author, date and countryPatient groupStudy type (level of evidence)Key resultsOutcomesStudy weaknesses
Capucci A et al, 1992, Italy62 patients with recent onset atrial fibrillation (⩽7 days), placebo versus amiodarone iv bolus followed by infusion or flecainide poRandomised single blind trialConversion to sinus rhythmas a percentageSmall numbers
at 3 hoursplacebo 29, amiodarone 16, flecainide 68Placebo group discontinued monitoring after 8 hours
at 8 hoursplacebo 48, amiodarone 37, flecainide 91
at 12 hoursamiodarone 47, flecainide 91
at 24 hoursamiodarone 89, flecainide 95
Donovan KD et al, 1995, Australia98 patients with acute onset atrial fibrillation (⩽72 h), placebo versus amiodarone iv or flecainide ivRCTConversion to sinus rhythmplacebo 7/32, amiodarone 11/32, flecainide 20/34Small numbers
<2 hoursplacebo 18/32, amiodarone 19/32, flecainide 23/34Power not shown
>2 and <8 hours
Boriani G et al, 1998, Italy417 patients with recent onset atrial fibrillation (⩽7 days), placebo versus amiodarone iv, flecainide po, propafenone iv or propafenone poCohortConversion to sinus rhythmas a percentage
at 1 hourplacebo 9, amiodarone 6, flecainide 13
at 3 hoursplacebo 18, amiodarone 25, flecainide 57
at 8 hoursplacebo 37, amiodarone 57, flecainide 75
Martinez-Marcos FJ et al, 2000, Spain150 patients with acute onset atrial fibrillation (⩽48 hrs). Amiodarone iv versus flecainide iv or propafenone ivRandomised single blind trialConversion to sinus rhythmas a percentage
at 1 houramiodarone 14, flecainide 29
at 8 hoursamiodarone 42, flecainide 82
at 12 hoursamiodarone 64, flecainide 90