Table 1
Author, date, and countryPatient groupStudy type (level of evidence)OutcomesKey resultsStudy weaknesses
Zubowicz VN and Gravier M, 1991, USA48 patients with early (<24 hour) human bites to the handProspective randomised controlled trialInfection rate: placebo v oral cephalosporin v IV cephalosporin + penicillin GInfection rate: 46.7% placebo v 0% oral/IV antibiotic (p<0.05)Small study population within each group
Broder J et al, 2004, USA127 patients with early (<24 hour) superficial human bites excluding to the hand, feet, or skin overlying jointsProspective double blind placebo controlled trialInfection rate: placebo v oral cephalosporin/penicillinInfection rate: 1.6% placebo v 0% antibiotic (p>0.05)Only investigated low risk bites