One or more of the following should be present in two or more systems to satisfy criteria for multi-system dysfunction: | |
A. Cardiovascular system | |
Heart rate <55/min | |
Mean arterial blood pressure <50 mm Hg | |
Systolic blood pressure <60 mm Hg | |
pH <7.25 with PaCO2 <50 mm Hg | |
Ventricular tachycardia or fibrillation | |
B. Respiratory system | |
Respiratory rate ⩽5/min or ⩾49/min | |
PaCO2 ⩾50 mm Hg | |
Dependant on ventilator on fourth day of organ system dysfunction | |
C. Renal | |
Urine output <480 ml/day or <160 ml/8 hours | |
Blood urea ⩾1 g/l | |
Serum creatinine >35 mg/l | |
D. Haematological | |
Packed cell volume ⩽20% | |
White blood cells ⩽1000/mm3 | |
Platelets ⩽20 000/mm3 | |
E. Hepatic | |
Bilirubin>60 mg/l and PT >4 s more than control | |
F. Central nervous system | |
Glasgow coma scale <6 | |