Table 2

Variables selected in the validation analysis

Variables	BayPAD included in the network	Available in the PISA-PED Study	Selected for the validation
BayPAD, Bayes Pulmonary embolism Assisted Diagnosis; CK-MB, Creatine Kinase; CT, Computed tomography; DVT, Deep venous thrombosis; ECG, electrocardiogram; PISA-PED, Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis.
Pre-existing disease
Chronic cardiovascular disease	Yes	Yes	Yes
Chronic pulmonary disease	Yes	Yes	Yes
Cancer	Yes	Yes	Yes
Hereditary DVT predisposing factors	Yes	No	No

Risk factors
Age	Yes	Yes	Yes
Sex	Yes	Yes	Yes
Immobilisation	Yes	Yes	Yes
Cigarette smoking	Yes	No	No
Central line	Yes	No	No
Surgery	Yes	Yes	Yes
Pregnancy	Yes	Yes	Yes
Chronic venous insufficiency	Yes	Yes	Yes
Oestrogen intake	Yes	Yes	Yes
Bone fractures	Yes	Yes	Yes
DVT prophylaxis	Yes	No	No

Symptoms
Dyspnoea	Yes	Yes	Yes
Orthopnoea	Yes	Yes	Yes
Fainting	Yes	Yes	Yes
Chest pain	Yes	Yes	Yes
Haemoptysis	Yes	Yes	Yes
Agitation	Yes	No	No
Lower limb discomfort	Yes	No	No
Cough	Yes	No	No

Signs
Lower limb unilateral oedema	Yes	Yes	Yes
Cyanosis	Yes	No	No
Fever>38 °C	No	Yes	No
Bronchospasmus	Yes	Yes	Yes
Systolic blood pressure	Yes	No	No
Tachypnoea	Yes	Yes	Yes
Tachycardia	No	Yes	No
Cardiac failure signs	Yes	Yes	Yes
Shock	Yes	No	No

Laboratory findings
D-dimer test	Yes	No	No
paO₂	Yes	Yes	Yes
paCO₂	Yes	Yes	Yes
CK-MB enzymes	Yes	No	No

ECG findings
ECG right heart overload signs	Yes	Yes	Yes
ECG acute myocardial infarction signs	Yes	No	No

Chest x rays
Consolidation (infarction)	Yes	Yes	Yes
Consolidation (no infarction)	No	Yes	No
Plate-like atelectasis	No	Yes	No
Pulmonary oedema	Yes	Yes	Yes
Elevation of half of the diaphragm	Yes	Yes	Yes
Unilateral pleural effusion	Yes	No	No
Pulmonary oligaemia	No	Yes	No
Amputation of hilar artery	No	Yes	No
Pneumonia	Yes	No	No

Imaging
Doppler ultrasounds of the lower limbs	Yes	No	No
Echocardiographic signs of pulmonary embolism	Yes	No	No
Ventilation/perfusion lung scan	Yes	No	No
Perfusion lung scan	Yes	Yes	Yes
Phlebography	Yes	No	No
Spiral CT scan	Yes	No	No
Pulmonary angiography	Yes	Yes	Yes