Table 3 Treatment regimens and co-interventions used in studies of intravenous magnesium sulphate
StudyMagnesium regimenControl regimenβ-agonist regimenCorticosteroid regimenCo-interventions
Bijani25 mg/kg over 30–45 min100 ml saline solutionSalbutamol (interval not stated)Corticosteroids (type not stated)Aminophylline
Silverman2 g loading dose over 10–15 min50 ml saline solutionAlbuterol 0, 30, 60, 120, 180 min125 mg IV MPNone stated
Porter2 g loading dose over 20 min50 ml saline solutionAlbuterol 20 min intervals125 mg IV MPNone stated
Bilaceroglu2 g loading dose100 ml of 5% dextroseSalbutamol 0, 30, 60, 120, 180 min125 mg MP if PEFR <40% predictedTheophylline
Boonyavorakul2 g loading dose2 ml sterile water in 50 ml salineSalbutamol 0, 20, 40, 60 min5 mg IV dexamethasoneNone stated
Scarfone75 mg/kg over 20 min (max 2.5 g)Saline solutionAlbuterol 0.15 mg/kg 0, 40, 80, 120 min1.0 mg/kg MP IV (max 125 mg)None stated
Ciarallo40 mg/kg over 20 min (max 2 g)100 ml saline solutionAlbuterol2 mg/kg MP IV (max 100 mg)Ipratropium
Gurkan40 mg/kg over 20 min (max 2 g)Saline solution equivalent volumeSalbutamol 0.15 mg/kg2 mg/kg MP IV (max 100 mg)None stated
Devi100 mg/kg over 35 minSaline solution equivalent volumeSalbutamol 0.15 mg/kgHydrocortisone IV/oral (no dose provided)Aminophylline
Ciarallo25 mg/kg over 20 min (max 2 g)Saline solution equivalent volumeAlbuterol 0.15 mg/kg2 mg/kg IV MPNone stated
Bloch2 g loading dose over 20 min50 ml saline solutionAlbuterol 0, 30, 60, 120, 180 min125 mg IV MP if initial FEV1 ⩽40% or oral steroids last 6/12Theophylline
Matusiewicz1.2 g loading dose over 15 min50 ml saline solutionSalbutamol at discretion of physician200 mg IV hydrocortisoneIpratropium neb, aminophylline IV
Tiffany2 g loading dose over 20 min followed by infusion of MgSO4 or placeboSaline solutionAlbuterol 30 min intervals125 mg IV MPAminophylline
Green2 g loading dose over 20 minNo placeboAlbuterol initially then hourly125 mg IV MPTheophylline β-agonist injection ephedrine
Skobeloff1.2 g loading dose over 20 min50 ml saline solutionMetaproterol/albuterol at physician discretion125 mg IV MPTheophylline IV
  • FEV1, forced expiratory volume in 1 s; IV, intravenous; MP, methylprednisolone; PEFR, peak expiratory flow rate.