Study | Magnesium regimens | Total amount magnesium used | Control regimen | Bronchodilator regimen | Co-interventions | |
Aggarwal | 1 ml MgSO4 (500 mg) (3 doses, 20 min apart) with β-agonist | 1500 mg (3×500 mg) | 1.5 ml distilled water7.5 ml normal saline | Salbutamol 1 ml | IV hydrocortisone + salbutamolDiscretion physician | |
Drobina | 125 mg MgSO4 0.25 ml of 50% solution (3 doses, 20 min apart) with β-agonist | 375 mg (3×125 mg) | 0.25 ml saline solution | 5 mg/ml albuterol + 2.5 ml ipratropium bromide | 50 mg oral prednisolone | |
Kokturk | Iso-osmolar MgSO4 (6.3%, 145 mg/dose) (20 min intervals) with β-agonist | 1015 mg (7×145 mg) | 2.5 ml isotonic saline solution | 2.5 mg salbutamol | 1 mg/kg MP IV | |
Mahajan | 2.5 ml isotonic MgSO4 (6.3%) solution) single dose with β-agonist | — | 2.5 ml saline solution | Albuterol 2.5 mg (0.5 ml) | 2 mg/kg prednisolone | |
Hughes | 2.5 ml isotonic MgSO4 (151 mg/dose) (3 doses at 30 min intervals) with β-agonist | 453 mg (3×151 mg) | 2.5 ml isotonic saline solution | 2.5 mg salbutamol | 100 mg hydrocortisone IV | |
Bessmertny | MgSO4 384 mg (64 mg/ml) in 6 ml sterile water (3 doses at 20 min intervals) after β-agonist | 1152 mg (3×384 mg) | 6 ml saline solution | Albuterol 2.5 mg/3 ml | 2 mg/kg hydrocortisone IV 6 hourly | |
Nannini | 3 ml isotonic MgSO4 (7.5 g/100 ml) single dose with β-agonist | 225 mg | 3 ml saline solution | Salbutamol | None stated | |
Mangat | 3 ml (95 mg) MgSO4 (4 doses, 20 min apart) | 380 mg (4×95 mg) | 3 ml salbutamol (2.5 mg) | Part of control regimen | 100 mg hydrocortisone IV | |
Meral | 2 ml MgSO4 (280 mmol/l) | — | 2.5 mg/2.5 ml salbutamol | Part of control regimen | Theophylline |
IV, intravenous; MP, methylprednisolone.