Case reports of naloxone use in acute valproic acid toxicity
| Reference | Age of patient | Plasma valproate concentration (mg/l) | Naloxone dose | Response to naloxone |
|---|---|---|---|---|
| Steiman et al 1979 | 19 months | 185 | 0.01 mg/kg | Coma reversed after 3 min. After 20 min, somnolence reversed with a second dose |
| Espinoza et al 2001 | 3 years | Not recorded | 0.1 mg | Coma and respiratory depression reversed within minutes |
| Roberge et al 2001 | 44 years | 138 | 2 mg | Obtundation reversed; response to a second dose after relapse at 1 h |
| Alberto et al 1989 | 22 years | 180.4 | 2 mg | Somnolence and respiratory depression reversed in 1 min |
| Montero 1999 | 21 years | 487.8 | 0.4 mg | Improvement in conscious level within minutes on both occasions |
| then 0.8 mg |