Grade and number of final clinical recommendations9
| Grade of recommendation | Number of recommendations in breathing difficulty |
| Grade A: high-quality meta-analyses, systematic review, randomised controlled trial with low risk of bias | 10 |
| Grade B: high-quality systematic reviews of case–control, cohort studies, high-quality case–control or cohort studies with a very low risk of bias | 5 |
| Grade C: well-conducted case–control or cohort studies with a low risk of bias or chance and a moderate probability that the relationship is causal and directly applicable to the target population and demonstrating overall consistency of results; or extrapolated evidence from high-quality systematic reviews of case–control or cohort studies or high-quality case–control or cohort studies with a very low risk of bias and a moderate probability that the relationship is causal | 17 |
| Grade D: Based on non-analytical studies, eg, case reports, case series, expert opinion or extrapolated evidence from well conducted case–control or cohort studies with a low risk of bias or chance and a moderate probability that the relationship is causal | 31 |
| Total number of statements in the guideline | 63 |