Characteristics of cohorts
| Cohort | n | Age, median (range) | MEWS, median (range) | Source % respiratory | Source % abdominal | No of organ failures (mean) | Mortality day 28, % |
| No shock: no interventions | 192 | 75 (0–99) | 6 (1–12) | 44.8 | 24.5 | 1.4 | 23.3 |
| No shock: RB only | 18 | 65 (18–93) | 6.5 (2–11) | 55.6 | 16.7 | 1.7 | 11.1 |
| No shock: sepsis six + RB | 143 | 70 (19–99) | 6.5 (1–15) | 48.3 | 18.9 | 1.6 | 4.2 |
| Shock: no interventions | 111 | 76 (44–101) | 6 (1–14) | 41.4 | 24.3 | 1.7 | 79.3 |
| Shock: EGDT only | 25 | 60 (20–89) | 6 (3–10) | 52.0 | 12.0 | 1.7 | 8.0 |
| Shock: sepsis six only | 34 | 77 (39–95) | 7 (3–11) | 32.4 | 35.3 | 1.9 | 97.1 |
| Shock: all interventions | 42 | 69 (30–86) | 7.5 (2–15) | 40.5 | 28.6 | 2.1 | 4.7 |
| p Value | <0.001 | <0.001 | 0.484 | 0.484 | 0.017 | <0.001 |
EGDT, early goal-directed therapy; MEWS, modified early warning score; RB, resuscitation bundle.