Glossary of terms
| Term | Definition/explanation |
| Hypoperfusion | ACCP/SCCM definitions: a SBP <90 mm Hg, mean blood pressure <65 mm Hg, a fall in SBP of >40 mm Hg, or a lactate of >2 mmol/l |
| Shock | The persistence of hypoperfusion despite fluid challenges |
| Cryptic shock | Hyperlactataemia (>2 mmol/l) despite normal blood pressure. |
| Resuscitation bundle | Combined evidence-based goals from the SSC that must be completed within 6 h for patients with severe sepsis, septic shock and/or lactate >4 mmol/l |
| Sepsis six | An operationalised version of the non-specialist tasks from within the resuscitation bundle (extras oxygen, urine output monitoring, exclusions: central venous access and vasopressors) |
| Early goal-directed therapy | A goal-directed resuscitation strategy to achieve predefined endpoints such as mixed venous oxygen saturation, base deficit, lactate and pH |
ACCP/SCCM, American College of Chest Physicians/Society of Critical Care Medicine; SBP, systolic blood pressure; SSC, Surviving Sepsis Campaign.