| Aikens et al (1999) USA24 | BDI | None | | | |
| Demiryoguran et al (2006) Turkey25 | HADS-A | None | NCCP mean=7.9 (SD=3.7) 31.2% scored ≥10
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| Eken et al (2010) Turkey26 | HADS | None | NCCP median=8, 38.1% scored ≥10 CCP median=8, 40% scored ≥10 (p=0.737)
| NCCP median=7, 52.1% scored ≥7 CCP median=7, 52.3% scored ≥7 (p=0.965)
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| Eslick and Talley (2008) Australia27 | | | Baseline: 21% in NCCP (95% CI 16% to 28%), 17% in CCP (95% CI 9% to 28%) 2 years: NCCP 12% (95% CI 6% to 21%) CCP 13% (95% CI 4% to 27%) 4 years: NCCP 19% (95% CI 10% to 30%) CCP 12% (95% CI 3% to 31%)
| Baseline: 9% in NCCP (95% CI 5% to 13%) 7% in CCP (95% CI 2% to 16%) 2 years: NCCP 7% (95% CI 2% to 14%) CCP 5% (95% CI 1% to 17%) 4 years: NCCP 2% (95% CI 1% to 8%) CCP 4% (95% CI 1% to 20%)
| NCCP patients: significant improvement in QoL between baseline and 2 years in role physical (baseline mean=33.68, 2 year mean=52.47, p<0.001), pain (baseline mean=59.11, 2 year mean=69.25, p=0.008), vitality (baseline mean=45.37, 2 year mean =53.05, p=0.02), social functioning (baseline mean=61.24, 2 year mean=72.35, p=0.001) and role emotional (baseline mean =65.19, 2 year mean=77.38, p=0.03). No significant differences between 2 and 4 years CCP patients: significant improvement in QoL between baseline and 2 years in role physical (baseline mean=25.67, 2 year mean=47.56, p=0.002), pain index (baseline mean=55.55, 2 year mean=73.76, p=0.003), social functioning (baseline mean=56.53, 2 year mean=73.87, p=0.002) and role emotional (baseline mean=62.96, 2 year mean=81.37, p=0.04). No significant differences between 2 and 4 years
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| Fagring et al (2008)20, Jerlock et al (2008)5 Sweden | Zung depression scale Trait anxiety inventory SF-36
| None | NCCP patients, 39.39% scored ≥43 Controls, 24.13% scored ≥43 Significantly more anxiety in male (Adjusted OR 2.2, 95% CI 1.4 to 3.5) and female (Adjusted OR 1.8, 95% CI 1.1 to 2.8) NCCP patients
| NCCP patients, 40.26% scored ≥39 Controls, 23.01% scored ≥39 Significantly more depression in male (Adjusted OR 2.3, 95% CI 1.4 to 3.6) and female (Adjusted OR 2.5, 95% CI 1.6 to 3.9) NCCP patients
| NCCP patients significantly more likely to receive low scores on SF-36 than controls on all subscales—all p<0.0001, except general health in all participants (p<0.01), general health in men (p=0.006), physical functioning in men (p=0.0001), and role emotional in men (p=0.001) |
| Kuijpers et al (2003) The Netherlands22 | HADS | None | 53.9% scored ≥8 for either anxiety or depression on HADS | 53.9% scored ≥8 for either anxiety or depression on HADS | |
| Mayou and Thompson (2002) UK28 | | | | | On admission, NCCP patients had better QoL than CCP patients in physical function (p<0.001), physical role limitation (p=0.002), social functioning (p=0.021), and pain (p=0.003). CCP patients had worse QoL on specific questions on everyday activities at 3 and 12 months (no figures given) |
| Shahid et al (2004) Pakistan29 | Aga Kahn University anxiety and depression scale | None | 58% scored above cut-off of 19 | 58% scored above the cut-off of 19 | |
| Soares-Filho et al (2009) Brazil30 | HADS | None | NCCP mean=8.20 (SD=4.5) PDC mean=6.29 (SD=3.96) (p<0.011) NCCP 53.5% scored ≥8 PDC 33.9% scored ≥8 (p=0.025)
| NCCP mean=4.70 (SD=3.82) PDC mean=4.86 (SD=4.07) (p=0.819) NCCP 25.4% scored ≥8 PDC 30.5% scored ≥8 (p=0.513)
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| Srinivasan and Joseph (2004) India23 | HADS | None | NCCP mean=6.13 CCP mean=4.16
| NCCP mean=4.10 CCP mean=2.93
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