Table A6

Type of thromboprophylaxis

Author, date and country	Patient group	Study type (level of evidence)	Outcomes	Key results	Study weaknesses
Gehling et al, January 1998, Germany	287 patients presenting with lower extremity injuries, who required immobilising bandages or casts	Randomised controlled trial in which thromboprophylaxis was administered in the form of a subcutaneous injection of divarin 1750 once daily in 143 patients and with Aspirin 2×500 mg orally in 144 patients. A clinical examination and colour-coded duplex sonography were performed after removal of the cast for detection of lower extremity venous thrombosis. A phlebography was performed for confirmation when thrombosis was suspected	Incidence of DVT in group receiving prophylactic LMWH	9/143 (6.3%)	Heterogenous cohort consisting of inpatients, outpatients and surgical patients. No distinction between symptomatic/asymptomatic disease
Gehling et al, January 1998, Germany			Incidence of DVT in group receiving prophylactic Aspirin	7/144 (4.8%)