Baseline characteristics and clinical and laboratory data of the patients included in the COPED-PAO study
| All patients (n=377) | Patients with copeptin levels >25.9 pmol/l (n=114) | Patients with copeptin levels ≤25.9 pmol/l (n=263) | p Value | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Age (years) (mean (SD) | 72 (13) | 70 (13) | 75 (11) | <0.001 |
| Male gender (n (%)) | 258 (68.8) | 82 (72.6) | 176 (67.2) | 0.36 |
| Arterial hypertension (n (%)) | 281 (74.5) | 90 (78.9) | 191 (72.6) | 0.24 |
| Diabetes mellitus (n (%)) | 141 (37.8) | 44 (39.3) | 97 (37.2) | 0.79 |
| Dyslipemia (n (%)) | 202 (53.9) | 59 (52.2) | 143 (54.6) | 0.76 |
| Current smoker (n (%)) | 118 (31.6) | 29 (25.7) | 89 (34.1) | 0.14 |
| Family history of early ischaemic cardiomyopathy (n (%)) | 37 (10.0) | 9 (8.1) | 28 (10.8) | 0.54 |
| Personal history of ischaemic cardiomyopathy (n (%)) | 132 (35.2) | 45 (39.8) | 87 (33.2) | 0.27 |
| On treatment with ASA (n (%)) | 203 (54.1) | 57 (50.9) | 146 (55.5) | 0.48 |
| Previous episode of acute heart failure (n (%)) | 61 (16.4) | 31 (27.4) | 30 (11.6) | <0.001 |
| Previous cerebrovascular disease (n (%)) | 42 (11.2) | 14 (12.3) | 28 (10.7) | 0.66 |
| Renal failure (creatinine >1.3 mg/dl) (n (%)) | 45 (12.1) | 24 (21.4) | 21 (8.0) | 0.001 |
| Chronic pneumopathy (n (%)) | 49 (13.2) | 16 (14.4) | 33 (12.6) | 0.77 |
| Acute episode characteristics | ||||
| Time from start of symptoms to ED arrival (in minutes) (median (25–75 percentiles)) | 90 (30–180) | 120 (30–195) | 90 (30–120) | 0.31 |
| Systolic blood pressure at ED arrival <100 mm Hg (n (%)) | 6 (1.6) | 4 (3.5) | 2 (0.8) | 0.07 |
| Systolic blood pressure at ED arrival >160 mm Hg (n (%)) | 110 (29.5) | 24 (21.2) | 86 (33.1) | <0.05 |
| Respiratory rate above 20 breaths per minute (n (%)) | 31 (10.6) | 13 (15.5) | 18 (8.6) | 0.13 |
| Room-air pulsioxymetry <90% (n (%)) | 5 (2.2) | 3 (4.7) | 2 (1.3) | 0.14 |
| Heart rate >100 beats per minute (n (%)) | 38 (10.1) | 16 (14.2) | 22 (8.4) | 0.13 |
| Blood urea nitrogen >mg/dl (n (%)) | 174 (52.1) | 66 (68.8) | 108 (45.4) | <0.001 |
| Hyponatremia (Na <135 mEq/l) (n (%)) | 27 (7.2) | 9 (8.0) | 18 (6.8) | 0.85 |
| Hypokalemia (K <3.5 mEq/l) (n (%)) | 14 (3.9) | 5 (4.6) | 9 (3.5) | 0.57 |
| Any raised troponin during ED stay (n (%)) | 183 (48.5) | 77 (67.5) | 106 (40.3) | <0.001 |
| Hospital admission (n (%)) | 366 (97.1) | 111 (97.4) | 255 (97.1) | 0.94 |
Data in italics Baseline clinical characteristics and acute (current) episode characteristics (includins clinical and laboratory data) of the patients included in COPED-PAO study.
ASA, acetylsalicylic acid; COPED, COPeptin in Emergency Department; ED, emergency department.