Clinical outcomes
| Intervention | Control | |
|---|---|---|
| n=6* | n=8† | |
| BP (mm Hg) | ||
| In ambulance: | n=6 | n=8 |
| Systolic mean (SD) | 184 (12) | 186 (13) |
| Diastolic mean (SD) | 90 (3) | 103 (15) |
| On admission to hospital: | n=6 | n=8 |
| Systolic mean (SD) | 171 (30) | 177 (20) |
| Diastolic mean (SD) | 91 (23) | 97 (16) |
| Dosage review (mean time from admission=7.8 h) | n=5 | n=7 |
| Systolic mean (SD) | 153 (38) | 179 (15) |
| Diastolic mean (SD) | 80 (20) | 95 (13) |
| 4 h after admission: | n=5 | n=7 |
| Systolic mean (SD) | 143 (47) | 159 (35) |
| Diastolic mean (SD) | 74 (23) | 79 (24) |
| 24 h after admission: | n=5 | n=7 |
| Systolic mean (SD) | 144 (36) | 144 (28) |
| Diastolic mean (SD) | 77 (20) | 81 (19) |
| 48 h after admission: | n=5 | n=6 |
| Systolic mean (SD) | 148 (40) | 154 (21) |
| Diastolic mean (SD) | 81 (19) | 86 (21) |
| Day 3: | n=5 | n=7 |
| Systolic mean (SD) | 126 (17) | 158 (32) |
| Diastolic mean (SD) | 74 (13) | 92 (19) |
| Day 7: | n=4 | n=7 |
| Systolic mean (SD) | 129 (7) | 155 (21) |
| Diastolic mean (SD) | 73 (3) | 91 (20) |
| NIHSS | ||
| n=6 | n=8 | |
| Admission median (IQR) | 4 (1–8) | 6 (3–11) |
| n=5 | n=7 | |
| Day 3 median (IQR) | 3 (2–3) | 3 (0–6) |
| Change from baseline to day 3 median (IQR)‡ | 0 (−2 to 2) | 2 (0–3) |
| n=4 | n=7 | |
| Day 7 median (IQR) | 2 (1–14) | 3 (0–5) |
| Change from baseline to day 7 median (IQR)‡ | 1 (−6 to 5) | 3 (2–4) |
*4/6 patients received ambulance dose of lisinopril only; 1/6 patients received 7 days of study treatment.
†4/8 patients received ambulance dose of placebo only; 3/8 patients received 7 days of placebo treatment.
‡Calculated baseline score minus day 7 score, positive change is improvement.
BP, blood pressure; NIHSS, National Institute of Health Stroke Scale.