Systemic inflammatory response syndrome (SIRS) |
SIRS is present if there are at least 2 of: |
▸ Temperature >38.3°C or <36.0°C ▸ Pulse >90/min ▸ RR >20/min ▸ New confusion/drowsiness ▸ White cell count >12 or <4×109/L ▸ Blood glucose >7.7 mmol/L (non-diabetic patients)
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Severity of sepsis |
Severity | Definition |
Uncomplicated sepsis | SIRS+presumed or confirmed infection |
Severe sepsis | Sepsis+one or more organ dysfunction criteria (other than shock):
▸ Bilateral lung infiltrates+new need for oxygen to maintain saturations >90% or bilateral lung infiltrates with PaO2/FiO2 ratio <300 mm Hg or 39.9 kPa ▸ Lactate >2.0 mmol/L ▸ Serum creatinine >176.8 μmol/L or urine output <0.5 mL/kg/h for two successive hours ▸ INR >1.5 or aPTT >60 s ▸ Platelet count <100×109/L ▸ Bilirubin >34.2 μmol/L
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Septic shock | Sepsis+shock
▸ Lactate >4 mmol/L at any time point ▸ Hypotension persisting after 30 mL/kg intravenous fluid, defined as:
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