Table 3

Key risks associated with the management of isolated distal deep vein thrombosis and supporting levels of evidence

Associated complicationEstimated riskLevel of evidence
With conservative management
 Fatal bleeding0%1−
 Major bleeding0%1−
 Propagation to the popliteal trifurcation or above9.1% (95% CI 7.1% to 10.6%)1−
 Acute pulmonary embolism3.2% (95% CI 0.9% to 5.5%)1−
 All-cause mortality0.9% (95% CI 0% to 2.3%)1−
With therapeutic anticoagulation
 Fatal bleeding0.37% (95% CI 0.36% to 0.38%)1++
 Major bleeding2.06% (95% CI 2.04% to 2.08%)1++
 Propagation to the popliteal trifurcation or above1.6% (95% CI 0.1% to 3.0%)1−
 Acute pulmonary embolism0%1−
 All-cause mortality0.7% (95% CI 0% to 2.0%)1−
  • Estimates from the literature4 ,35–37 are presented for 3/12 follow-up rates with CIs. Levels of evidence are graded as per the Scottish Intercollegiate Guideline Network recommendations. Bleeding estimates are based on the use of phased anticoagulation and oral vitamin K antagonists only. Major bleeding episodes are standardised as per the definition provided by the International Society for Thrombosis and Haemostasis.74