Table 5

Reasons for not being thrombolysed (n=2019)

Reason: time
 Too late intravenous512.5%
 Too late intravenous and no indication intra-arterial20310.1%
 Too late intravenous and intra-arterial41820.7%
 Unknown onset*66733.0%
Reason: severity
 Too mild†92445.8%
 Too severe‡251.2%
 Rapid improvement to below threshold180.9%
Reason: age
 >80 years till 2006§28514.1%
Reason: imaging
 Too large infarct¶321.6%
 Too little penumbra120.6%
 Too large infarct and too little penumbra70.3%
 Large subacute infarct on imaging**180.9%
 Other/intracranial haemorrhage231.1%
Reason: high bleeding risk
 INR elevated††1748.6%
 Recent intervention190.9%
 Previous intracranial haemorrhage170.8%
 Intracranial vascular malformation140.7%
 Full dose heparin or LMWH201.0%
 Other bleeding risk241.2%
Reason: other
 No good reason according to hospital recommendations (thrombolysis missed)572.8%
 Recent stroke§§512.5%
 Stroke uncertain582.9%
 Epileptic seizure130.6%
  • *>60 min uncertainty and too late for thrombolysis.

  • †NIHSS <6 until September 2006, NIHSS <4 from October 2006 without isolated hemianopia or aphasia thereafter.

  • ‡NIHSS>25 till September 2006, no limit thereafter.

  • §Since October 2006: >80 and significant comorbidity or dependency.

  • ¶Non-contrast image or perfusion image.

  • **Defined as a poorly demarcated, hypodense territorial lesion with mild local swelling or absence of the usual atrophy of chronic stroke lesions.

  • ††>1.2 before October 2006 and >1.5 thereafter.

  • ‡‡<100 000/mm3.

  • §§Clinically or radiologically <3 months.

  • INR, international normalised ratio; LMWH, low molecular weight heparin; NIHSS, National Institute of Health Stroke Scale score.