Multivariate analysis of reasons for non-thrombolysis comparing the first (n=959) with the second (n=1060) half of the observation period
| Patients (n=2019) | 2003–2006 | 2006–2011 | OR | p Value | 95% CI |
|---|---|---|---|---|---|
| Too late intravenous and no indication intra-arterial | 127 (13%) | 76 (7%) | 1.79* | 0.010 | 1.15 to 2.78 |
| Unknown onset | 268 (28%) | 399 (38%) | 0.69* | 0.008 | 0.53 to 0.91 |
| Too mild stroke | 442 (46%) | 497 (47%) | 0.66* | 0.002 | 0.51 to 0.86 |
| Too severe stroke | 20 (2%) | 5 (1%) | 10.56* | 0.029 | 1.28 to 87.42 |
| Rapid improvement to below threshold | 16 (2%) | 2 (0.2%) | 5.43 | 0.109 | 0.69 to 43.01 |
| Age >80 years | 183 (19%) | 102 (10%) | 2.65* | 0.000 | 1.76 to 3.99 |
| Intracranial haemorrhage | 3 (0.3%) | 20 (2%) | 0.11* | 0.004 | 0.02 to 0.50 |
| Other bleeding reasons | 3 (0.3%) | 21 (2%) | 0.18* | 0.020 | 0.04 to 0.77 |
| Stroke uncertain | 10 (1%) | 48 (5%) | 0.19* | 0.000 | 0.08 to 0.44 |
| Comorbidity/dependency | 21 (2%) | 64 (6%) | 0.16* | 0.000 | 0.09 to 0.31 |
| Diabetes mellitus | 132 (14%) | 200 (19%) | 0.53* | 0.000 | 0.39 to 0.72 |
| Hyperlipidaemia | 589 (61%) | 707 (67%) | 0.53* | 0.000 | 0.40 to 0.70 |
| Probable atherosclerotic stroke mechanism (<50% stenosis) | 151 (16%) | 152 (14%) | 1.50* | 0.023 | 1.06 to 2.11 |
| Microangiopathic stroke mechanism | 171 (18%) | 149 (14%) | 1.72* | 0.002 | 1.21 to 2.43 |
OR >1 means more likely in first half and <1 means more likely in second half of observation period.
Asterisk (*), significant on p<0.05 level. Definitions of reasons for non-thrombolysis see text/table 5.