Table 4

Accuracy of NEXUS II to detect clinically significant ICI, tested by presence of any risk criteria (of the seven) and clinician accuracy to detect ICI without NEXUS (n=20 109)

Risk criteria
PositiveNegative
Accuracy NEXUS II Total Cohort (n=20 109)
 Positive ICI3794
 Negative ICI10 4069320
 Sensitivity (95% CI)379/38399.0 (97.3 to 99.7)
 Specificity (95% CI)9320/19 72647.2 (46.5 to 47.9)
 PPV (95% CI)379/10 7853.5 (3.2 to 3.9)
 NPV (95% CI)9320/9324100.0 (99.9 to 100.0)
Accuracy NEXUS II initial CT scan in ED (n=1962)
 Positive ICI3734
 Negative ICI1429156
 Sensitivity (95% CI)373/37798.9 (97.3 to 99.7)
 Specificity (95% CI)156/15859.8 (8.4 to 11.4)
 PPV (95% CI)373/180220.7 (18.8 to 22.6)
 NPV (95% CI)156/16097.5 (93.7 to 99.3)
Accuracy NEXUS II CT at any time (n=2087)
 Positive ICI3794
 Negative ICI1497207
 Sensitivity (95% CI)379/38399.0 (97.3 to 99.7)
 Specificity (95% CI)207/170412.1 (10.6 to 13.8)
 PPV (95% CI)379/187620.2 (18.4 to 22.1)
 NPV (95% CI)207/21198.1 (95.2 to 99.5)