Accuracy of NEXUS II to detect clinically significant ICI, tested by presence of any risk criteria (of the seven) and clinician accuracy to detect ICI without NEXUS (n=20 109)
| Risk criteria | ||
| Positive | Negative | |
| Accuracy NEXUS II Total Cohort (n=20 109) | ||
| Positive ICI | 379 | 4 |
| Negative ICI | 10 406 | 9320 |
| Sensitivity (95% CI) | 379/383 | 99.0 (97.3 to 99.7) |
| Specificity (95% CI) | 9320/19 726 | 47.2 (46.5 to 47.9) |
| PPV (95% CI) | 379/10 785 | 3.5 (3.2 to 3.9) |
| NPV (95% CI) | 9320/9324 | 100.0 (99.9 to 100.0) |
| Accuracy NEXUS II initial CT scan in ED (n=1962) | ||
| Positive ICI | 373 | 4 |
| Negative ICI | 1429 | 156 |
| Sensitivity (95% CI) | 373/377 | 98.9 (97.3 to 99.7) |
| Specificity (95% CI) | 156/1585 | 9.8 (8.4 to 11.4) |
| PPV (95% CI) | 373/1802 | 20.7 (18.8 to 22.6) |
| NPV (95% CI) | 156/160 | 97.5 (93.7 to 99.3) |
| Accuracy NEXUS II CT at any time (n=2087) | ||
| Positive ICI | 379 | 4 |
| Negative ICI | 1497 | 207 |
| Sensitivity (95% CI) | 379/383 | 99.0 (97.3 to 99.7) |
| Specificity (95% CI) | 207/1704 | 12.1 (10.6 to 13.8) |
| PPV (95% CI) | 379/1876 | 20.2 (18.4 to 22.1) |
| NPV (95% CI) | 207/211 | 98.1 (95.2 to 99.5) |