Table 5

Accuracy of NEXUS II to detect clinically significant ICI, tested by presence of any risk criteria (of the seven) in children aged <3 and 3 to <18 years

Total cohort, <3 yearsTotal cohort, 3 to <18 years
Risk criteriaRisk criteria
PositiveNegativePositiveNegative
 Positive ICI1300Positive ICI2494
 Negative ICI42393503Negative ICI61675817
 Sensitivity (95% CI)130/130100.0 (97.2 to 100.0)Sensitivity (95% CI)249/25398.4 (96.0 to 99.6)
 Specificity (95% CI)3503/774245.2 (44.1 to 46.4)Specificity (95% CI)5817/11 98448.5 (47.6 to 49.4)
 PPV (95% CI)130/43693.0 (2.5 to 3.5)PPV (95% CI)249/64163.9 (3.4 to 4.4)
 NPV (95% CI)3503/3503100.0 (99.9 to 100.0)NPV (95% CI)5817/582199.9 (99.8 to 100.0)
  • ICI, intracranial injury; NPV, negative predictive value; PPV, positive predictive value.