Table 2

Clinical asthma scores used as primary outcome measures

StudyTiming of score in hoursPrimary outcome definedTotal number of studies
Pulmonary index scoreAllen and Macias27 0, 0.5, 1.5, 2Percentage of patients with reduction in score by 2 over 2-hour time of drug infusion4
Bien et al 28 0, 8, 16, 24Difference in score between treatment and placebo at defined intervals
Carter et al 29 0, 1, 3, 6, 12, 24, 36Difference in score between intervention and placebo group at time intervals
Scarfone et al 30 0.33, 0.5, 0.66, 1, 1.33, 2Degree of change over 120 min
Clinical asthma severity score of Asthma AustraliaBrowne et al 31 2, 4, 8, 12, 24Percentage with persistent moderate asthma at specified time intervals1
Clinical asthma score, modified from pulmonary index scoreBogie et al 32 0, 1, 2, 4, 6, 12, 24Mean improvement in score over 24 hours6
Devi et al 33 0.5, 1, 2, 3, 7Improvement in score at time intervals measured after cessation of drug infusion
DiGiulio et al 34 0 then twice dailyTime to reach study discharge criteria score of 2 and rate of improvement
Nuhoğlu et al 35 2, 6, 12 and 24 hoursDifference in score at 24 hours
Singhi et al 36 1  hourTreatment success, as defined by improvement of 4 or more points in score 1 hour after drug commencement
Wheeler et al 13 3, 6, 9, 12, 24 and every 12 hours afterScore improvement from admission to discharge from intensive care
Asthma severity score by Bishop et al 37 Roberts et al 38 0, 1, 2, 6, 12, 24Difference in score at 2 and 6.5 hours1
Wood and Downe asthma scoreGürkan et al 39 0.25, 0.5, 0.75, 1, 1.25, 1.5Difference in score between groups3
Watanatham et al 40 0.33, 0.66, 1, 2, 3, 4Comparative score between groups at 60 min
Daengsuwan and Watanatham41 0.20, 0.40, 1, 2, 4Comparative score between groups at 60 min
Modified Wood and Downe asthma scoreReam et al 42 Not specifiedTime to score equal to or less than 31
Asthma score not specifiedHambleton and Stone43 1, 2, 4, 6, 12, 18, 24Mean value of score over first 24 hours6
Hussein et al 44 Not specifiedDifference in score between two groups—timing not specified
Naao et al 45 At 24 hours Symptom score at 24 hours
Needleman et al 46 12 hourlyOverall improvement in score in comparative groups
Pierson et al 47 Not specifiedNot specified
Boeschoten48 Not specifiedReduction by 2 points at 1  hour
Preschool respiratory assessment measureTiwari et al 49 0.5, 1, 1.5, 2, 2.5, 3, 24Change in score at 3 hours1