IM: n=150 | PO: n=150 | P value* | |
Pain level assessed by numeric rating score (NRS) | |||
Baseline (t0) NRS median, 95% CI | 7 (7–7) | 7 (6–7) | 0.056 |
NRS at t5 | 7 (7–7) | 6 (6–7) | 0.028 |
NRS at t10 | 6 (6–6) | 6 (6–7) | 0.113 |
NRS at t15 | 5 (5–6) | 5 (5–6) | 0.942 |
NRS at t20 | 4 (4–4) | 4 (4–5) | 0.002 |
NRS at t25 | 3 (3–3) | 3 (3–4) | 0.0001 |
NRS at t30 | 2 (2–2) | 2 (2–2) | 0.0001 |
NRS at t45 | 2 (2–2) | 2 (2–2) | 0.0001 |
NRS at t60 | 1 (1–1) | 2 (2–2) | 0.0001 |
Primary outcome: 50% NRS reduction within 30 min | |||
n reaching outcome | 149 | 130 | |
Proportion (95% CI) reaching outcome | 99.3 (96.3 to 100) | 86.7 (80.2 to 91.7) | <0.001 |
Secondary outcome: 2-point NRS drop within 30 min | |||
n reaching outcome | 149 | 148 | |
Proportion (95% CI) reaching outcome | 99.3 (96.3 to 100) | 98.7 (95.2 to 99.8) | 1.00 |
↵*Kruskal-Wallis equality of population rank test.