Table 2

Pain score reductions and study endpoints

IM: n=150PO: n=150P value*
Pain level assessed by numeric rating score (NRS)
 Baseline (t0) NRS median, 95% CI7 (7–7)7 (6–7)0.056
 NRS at t57 (7–7)6 (6–7)0.028
 NRS at t106 (6–6)6 (6–7)0.113
 NRS at t155 (5–6)5 (5–6)0.942
 NRS at t204 (4–4)4 (4–5)0.002
 NRS at t253 (3–3)3 (3–4)0.0001
 NRS at t302 (2–2)2 (2–2)0.0001
 NRS at t452 (2–2)2 (2–2)0.0001
 NRS at t601 (1–1)2 (2–2)0.0001
Primary outcome: 50% NRS reduction within 30 min
 n reaching outcome149130
 Proportion (95% CI) reaching outcome99.3 (96.3 to 100)86.7 (80.2 to 91.7)<0.001
Secondary outcome: 2-point NRS drop within 30 min
 n reaching outcome149148
 Proportion (95% CI) reaching outcome99.3 (96.3 to 100)98.7 (95.2 to 99.8)1.00
  • *Kruskal-Wallis equality of population rank test.