Table 2

Test characteristics of the decision aids evaluated, using the Siemens ADVIA Centaur hs-cTnI assay at the time of arrival in the ED for a diagnosis of AMI

Decision aidSensitivity (95% CI)Specificity
(95% CI)
PPV
(95% CI)
NPV
(95% CI)
Number (%) ruled outIncidence of any 30 day MACE in patients who would be ‘ruled out’, n (%)
LoQ (<3 ng/L, unrounded)
(n=999)
99.2
(95.9 to 100.0)
33.1
(30.0 to 36.1)
18.4
(17.7 to 19.2)
99.7
(97.6 to 100.0)
288 (28.8)3 (1.0)
T-MACS
(n=970)
99.2
(95.7 to 100.0)
53.3
(49.9 to 56.7)
24.1
(22.8 to 25.5)
99.8
(98.5 to 100.0)
451 (46.5)5 (1.1)
HEART score
(n=874)
91.8
(85.0 to 96.2)
38.6
(35.1 to 42.2)
17.7
(16.6 to 18.9)
97.0
(94.6 to 98.4)
304 (34.9)9 (3.0)
TIMI score
(n=940)
97.5
(92.9 to 99.5)
22.2
(19.4 to 25.2)
15.6
(15.0 to 16.3)
98.4
(95.2 to 99.5)
182 (19.4)3 (1.6)
EDACS score
(n=844)
96.2
(92.2 to 99.4)
55.1
(51.4 to 58.7)
24.3
(22.8 to 25.9)
99.3
(97.8 to 99.8)
408 (48.3)3 (0.7)
  • AMI, acute myocardial infarction; EDACS, Emergency Department Assessment of Chest Pain; HEART, History, ECG, Age, Risk factors and Troponin; hs-cTnI, high-sensitivity cardiac troponin I; LoQ, limit of quantification; MACE, major adverse cardiac events; NPV, negative predictive value; PPV, positive predictive value; TIMI, Thrombolysis in Myocardial Infarction; T-MACS, Troponin-only Manchester Acute Coronary Syndromes.