S100B sensitivities and specificities to predict clinically significant intracranial haemorrhage (ICH) and all lesions
| Clinically significant ICH | Any ICH | |
| Blood sampling within 6 hours in all patients | ||
| Sensitivity, % | 18.2 (95% CI: 2.3 to 51.8) | 17.7 (95% CI: 3.8 to 43.4) |
| Specificity, % | 88.5 (95% CI: 84.2 to 91.7) | 88.5 (95% CI: 84.3 to 91.8) |
| NPV, % | 96.8 (95% CI: 94.0 to 98.5) | 95.0 (95% CI: 91.8 to 97.3) |
| PPV, % | 5.3 (95% CI: 0.6 to 17.8) | 7.9 (95% CI: 1.7 to 21.4) |
| Patients, n | 320 | 320 |
| Blood sampling within 24 hours in all patients | ||
| Sensitivity, % | 16.7 (95% CI: 4.7 to 37.4) | 13.5 (95% CI: 4.5 to 28.8) |
| Specificity, % | 88.5 (95% CI: 85.2 to 91.3) | 88.4 (95% CI: 85.0 to 91.2) |
| NPV, % | 95.2 (95% CI: 92.7 to 97.1) | 93.4 (95% CI: 89.4 to 94.7) |
| PPV, % | 7.1 (95% CI: 1.9 to 17.3) | 8.9 (95% CI: 2.9 to 19.6) |
| Patients, n | 476 | 476 |
| Blood sampling within 6 hours in isolated mTBI | ||
| Sensitivity, % | 66.7 (95% CI: 9.4 to 99.2) | 66.7 (95% CI: 9.4 to 99.2) |
| Specificity, % | 93.7 (95% CI: 87.4 to 97.4) | 93.7 (95% CI: 87.4 to 97.4) |
| NPV, % | 99.1 (95% CI: 94.8 to 99.9) | 99.1 (95% CI: 94.8 to 99.9) |
| PPV, % | 22.2 (95% CI: 2.8 to 60.0) | 22.2 (95% CI: 2.8 to 60.0) |
| Patients, n | 114 | 114 |
| Blood sampling within 24 hours in isolated mTBI | ||
| Sensitivity, % | 25.0 (95% CI: 3.2 to 65.1) | 22.2 (95% CI: 2.8 to 60.0) |
| Specificity, % | 89.6 (95% CI: 83.9 to 93.8) | 89.6 (95% CI: 83.8 to 93.8) |
| NPV, % | 96.1 (95% CI: 91.7 to 98.6) | 95.4 (95% CI: 90.8 to 98.1) |
| PPV, % | 10.5 (95% CI: 1.3 to 33.1) | 10.5 (95% CI: 1.3 to 33.1) |
| Patients, n | 172 | 172 |
mTBI, mild traumatic brain injury; NPV, negative predictive value; PPV, positive predictive value.