Patients with post-randomisation scans by baseline injury severity and treatment group
| Patients with post-randomisation scan (n=1431/1767) | TXA group | Placebo group | RR (95% CI) | P value (two-tailed) | |
| Glasgow Coma Score (GCS) | |||||
| Mild (GCS 13 to 15) | 64 (4%) | 32/47 (68%) | 32/45 (71%) | 0.96 (0.73 to 1.26) | 0.75 |
| Moderate (GCS 9 to 12) | 425 (30%) | 211/264 (80%) | 214/267 (80%) | 1.00 (0.92 to 1.09) | 0.95 |
| Severe (GCS 3 to 8) | 942 (66%) | 472/573 (82%) | 470/570 (82%) | 1.00 (0.95 to 1.05) | 0.97 |
| Pupil reaction | |||||
| Both react | 1064 (74%) | 529/637 (83%) | 535/651 (82%) | 1.01 (0.96 to 1.06) | 0.68 |
| One reacts | 174 (12%) | 83/97 (86%) | 91/105 (87%) | 0.99 (0.88 to 1.10) | 0.82 |
| None react | 157 (11%) | 82/124 (66%) | 75/108 (69%) | 0.95 (0.80 to 1.14) | 0.59 |
| Unable to assess | 35 (2%) | 20/25 (80%) | 15/18 (83%) | 0.96 (0.72 to 1.28) | 0.78 |
RR, relative risk; TXA, tranexamic acid.