Table 1

Baseline demographic and clinical characteristics

All patients
(n=1767)
TXA group
(n=884)
Placebo group
(n=883)
Sex
 Male1413 (80%)701 (79%)712 (81%)
 Female354 (20%)183 (21%)171 (19%)
Age
 Median (IQR) age in years45 (29 to 63)45 (29 to 64)45 (29 to 63)
Glasgow Coma Score (GCS)
 Mild (13 to 15)92 (5%)47 (5%)45 (5%)
 Moderate (9 to 12)532 (30%)264 (30%)268 (30%)
 Severe (3 to 8)1143 (65%)573 (65%)570 (65%)
 Median (IQR) GCS7 (3 to 10)7 (3 to 10)7 (3 to 10)
Pupil reaction
 Both react1289 (73%)637 (72%)652 (74%)
 One reacts202 (11%)97 (11%)105 (12%)
 None react232 (13%)124 (14%)108 (12%)
 Unable to assess43 (2%)25 (3%)18 (2%)
 Unknown1 (<1%)1 (<1%)0 (0%)
Systolic blood pressure
 <9027 (2%)14 (2%)13 (1%)
 90 to 119370 (21%)194 (22%)176 (20%)
 ≥1201362 (77%)672 (76%)690 (78%)
 Unknown8 (<1%)4 (<1%)4 (<1%)
Median (IQR) systolic blood pressure136 (120 to 155)136 (120 to 156)136 (121 to 154)
Hours since injury
 ≤1166 (9%)77 (9%)89 (10%)
 >1 to ≤31184 (67%)596 (67%)588 (67%)
 >3417 (24%)211 (24%)206 (23%)
Pre-randomisation CT scan
 Yes1147 (65%)*568 (64%)579 (66%)
 No615 (35%)313 (35%)302 (34%)
 Unknown5 (<1%)3 (<1%)2 (<1%)
Median (IQR) hours from injury to scan1.8 (1.4 to 2.4)1.8 (1.5 to 2.4)1.8 (1.4 to 2.3)
  • Data are n (%) of patients, unless otherwise indicated.

  • *12 unavailable due to technical problems (4 TXA and 8 placebo).

  • TXA, tranexamic acid.