Baseline demographic and clinical characteristics
| All patients (n=1767) | TXA group (n=884) | Placebo group (n=883) | |
| Sex | |||
| Male | 1413 (80%) | 701 (79%) | 712 (81%) |
| Female | 354 (20%) | 183 (21%) | 171 (19%) |
| Age | |||
| Median (IQR) age in years | 45 (29 to 63) | 45 (29 to 64) | 45 (29 to 63) |
| Glasgow Coma Score (GCS) | |||
| Mild (13 to 15) | 92 (5%) | 47 (5%) | 45 (5%) |
| Moderate (9 to 12) | 532 (30%) | 264 (30%) | 268 (30%) |
| Severe (3 to 8) | 1143 (65%) | 573 (65%) | 570 (65%) |
| Median (IQR) GCS | 7 (3 to 10) | 7 (3 to 10) | 7 (3 to 10) |
| Pupil reaction | |||
| Both react | 1289 (73%) | 637 (72%) | 652 (74%) |
| One reacts | 202 (11%) | 97 (11%) | 105 (12%) |
| None react | 232 (13%) | 124 (14%) | 108 (12%) |
| Unable to assess | 43 (2%) | 25 (3%) | 18 (2%) |
| Unknown | 1 (<1%) | 1 (<1%) | 0 (0%) |
| Systolic blood pressure | |||
| <90 | 27 (2%) | 14 (2%) | 13 (1%) |
| 90 to 119 | 370 (21%) | 194 (22%) | 176 (20%) |
| ≥120 | 1362 (77%) | 672 (76%) | 690 (78%) |
| Unknown | 8 (<1%) | 4 (<1%) | 4 (<1%) |
| Median (IQR) systolic blood pressure | 136 (120 to 155) | 136 (120 to 156) | 136 (121 to 154) |
| Hours since injury | |||
| ≤1 | 166 (9%) | 77 (9%) | 89 (10%) |
| >1 to ≤3 | 1184 (67%) | 596 (67%) | 588 (67%) |
| >3 | 417 (24%) | 211 (24%) | 206 (23%) |
| Pre-randomisation CT scan | |||
| Yes | 1147 (65%)* | 568 (64%) | 579 (66%) |
| No | 615 (35%) | 313 (35%) | 302 (34%) |
| Unknown | 5 (<1%) | 3 (<1%) | 2 (<1%) |
| Median (IQR) hours from injury to scan | 1.8 (1.4 to 2.4) | 1.8 (1.5 to 2.4) | 1.8 (1.4 to 2.3) |
Data are n (%) of patients, unless otherwise indicated.
*12 unavailable due to technical problems (4 TXA and 8 placebo).
TXA, tranexamic acid.