Biomarker/clinical indicator performance to predict severe COVID-19 outcomes
| Biomarker/clinical indicator | AUC (95% CI) | Sensitivity at Youden’s index | Specificity at Youden’s index |
| CRP (n=179) | 0.69 (0.59 to 0.78) | 0.77 | 0.55 |
| Neutrophils (n=185) | 0.53 (0.43 to 0.64) | 0.44 | 0.69 |
| Lymphocytes (n=185) | 0.62 (0.53 to 0.72) | 0.85 | 0.38 |
| NLR (n=185) | 0.62 (0.53 to 0.71) | 0.82 | 0.43 |
| IL-6 (n=125) | 0.77 (0.65 to 0.88) | 0.70 | 0.83 |
| KL-6 (n=149) | 0.51 (0.38 to 0.65) | 0.21 | 0.92 |
| suPAR (n=150) | 0.81 (0.72 to 0.88) | 0.82 | 0.65 |
| Procalcitonin (n=150) | 0.72 (0.62 to 0.81) | 0.94 | 0.43 |
| Ferritin (n=149) | 0.64 (0.53 to 0.74) | 0.59 | 0.69 |
| LDH (n=149) | 0.62 (0.51 to 0.72) | 0.55 | 0.69 |
| Troponin (n=149) | 0.70 (0.6 to 0.79) | 0.88 | 0.45 |
| BNP (n=149) | 0.64 (0.53 to 0.74) | 0.67 | 0.58 |
| Age (n=187) | 0.70 (0.62 to 0.77) | 0.95 | 0.41 |
| NEWS2 score (n=182) | 0.70 (0.60 to 0.79) | 0.41 | 0.88 |
| CURB-65 (n=180) | 0.65 (0.55 to 0.73) | 0.72 | 0.54 |
| Radiographic severity score (n=182) | 0.60 (0.49 to 0.71) | 0.36 | 0.91 |
AUC, area under the curve; BNP, B-type natriuretic peptide; CRP, C reactive protein; IL-6, interleukin-6; KL-6, Krebs von den Lungen 6; LDH, lactate dehydrogenase; NLR, neutrophil:lymphocyte ratio; suPAR, soluble urokinase plasminogen activator receptor.