Event-time-to-troponin and MACE, threshold with AUC, 95% CI, negative and positive predictive values (NPV and PPV) of the original HEART Score versus the preHEART Score of the index cohort and DeLong test for significance difference of non-parametric ROC curves. n=1208
| ETTT/% | HEART | preHEART | HEART versus preHEART | ||||||
| MACE NPV | MACE PPV | ROC | 95% CI | MACE NPV | MACE PPV | ROC | 95% CI | P value | |
| 0 hours/100 | 98.5% | 35.4% | 0.81 | 0.78 to 0.83 | 99.3% | 49.4% | 0.85 | 0.82 to 0.89 | 0.01 |
| 1 hour/78.0 | 98.1% | 32.8% | 0.80 | 0.75 to 0.85 | 99.0% | 49.2% | 0.85 | 0.81 to 0.89 | 0.07 |
| 2 hours/59.6 | 98.1% | 33.0% | 0.82 | 0.77 to 0.88 | 99.2% | 51.0% | 0.86 | 0.82 to 0.91 | 0.35 |
| 3 hours/50.6 | 97.7% | 31.1% | 0.81 | 0.75 to 0.88 | 99.0% | 54.8% | 0.86 | 0.81 to 0.91 | 0.15 |
| 4 hours/43.3 | 98.2% | 32.4% | 0.82 | 0.75 to 0.88 | 98.9% | 51.4% | 0.86 | 0.81 to 0.92 | 0.32 |
| 5 hours/40.0 | 98.0% | 30.3% | 0.81 | 0.74 to 0.89 | 98.7% | 50.0% | 0.86 | 0.79 to 0.92 | 0.66 |
AUC, area under the ROC curves; ETTT, event time to troponine; HEART, history, ECG, age, risk factors and troponin; MACE, major adverse cardiac event; NPV, negative predictive value; PPV, positive predictive value; preHEART, prehospital HEART; ROC, receiver operating characteristic.