Table 2

Diagnostic accuracy of the algorithms for ruling out 30-day MACE

Sensitivity %
(95% CI)
Specificity %
(95% CI)
NPV
(95% CI)
LR−
(95% CI)
30-day MACE
 HEART score94.8 (89.1 to 98.1)60.2 (56.7 to 63.5)98.8 (97.4 to 99.5)0.09 (0.04 to 0.19)
 HEART 0-hour/1-hour Pathway99.1 (95.3 to 99.9)56.7 (53.3 to 60.2)99.8 (98.5 to 100.0)0.02 (0.00 to 0.11)
 EDACS 0-hour/1-hour ADP96.7 (91.4 to 99.1)56.1 (52.7 to 59.6)99.1 (97.8 to 99.7)0.06 (0.02 to 0.16)
Index visit MI
 HEART score94.7 (86.9 to 98.5)57.5 (54.2 to 60.9)99.2 (98.0 to 99.7)0.09 (0.04 to 0.24)
 HEART 0-hour/1-hour Pathway100.0 (95.2 to 100.0)54.2 (50.8 to 57.5)100.0 (99.2 to 100)0.00 (0-NaN)
 EDACS 0-hour/1-hour-ADP98.7 (92.8 to 100.0)53.8 (50.4 to 57.2)99.8 (98.5 to 100.0)0.02 (0.00 to 0.17)
  • ADP, accelerated diagnostic protocol; EDACS, Emergency Department Assessment of Chest Pain Score; HEART, History, ECG, Age, Risk Factors and Troponin; LR−, negative likelihood ratio; MACE, major adverse cardiac events; NPV, negative predictive value.