Patient characteristics
| All patients n=939 | HEART score ≤3 n=501 | HEART 0-hour/1-hour Pathway rule-out n=468 | EDACS 0-hour/1-hour ADP rule-out n=466 | |
| General information | ||||
| Age, years mean, SD | 60.6 (17.4) | 50.3 (15.5) | 49.5 (15.1) | 50.0 (15.4) |
| Gender, male | 514 (54.7%) | 251 (50.1%) | 229 (48.9%) | 195 (41.8%) |
| Arrival by ambulance | 386 (41.1%) | 134 (26.7%) | 119 (25.4%) | 124 (26.6%) |
| History of | ||||
| Myocardial infarction | 188 (20.0%) | 14 (2.8%) | 14 (3.0%) | 29 (6.2%) |
| Stable angina | 197 (21.0%) | 17 (3.4%) | 14 (3.0%) | 26 (5.6%) |
| CABG | 81 (8.6%) | 1 (0.2%) | 1 (0.2%) | 3 (0.6%) |
| PCI | 164 (17.5%) | 18 (3.6%) | 18 (3.8%) | 27 (5.8%) |
| Diabetes mellitus type 1 or 2 | 134 (14.3%) | 17 (3.4%) | 16 (3.4%) | 29 (6.2%) |
| Hypertension | 415 (44.2%) | 96 (19.2%) | 82 (17.5%) | 108 (23.2%) |
| Stroke/TIA | 85 (9.1%) | 2 (0.4%) | 2 (0.4%) | 13 (2.8%) |
| Other risk factors | ||||
| Current smoker | 122 (13.0%) | 73 (14.6%) | 68 (14.5%) | 71 (15.2%) |
| Family history of CAD* | 226 (24.1%) | 117 (23.4%) | 114 (24.4%) | 127 (27.3%) |
| BMI, mean, SD | 27.0 (7.5) | 26.3 (6.3) | 26.3 (6.4) | 26.6 (6.6) |
| Current medications | ||||
| Aspirin/ADP inhibitor | 274 (29.2%) | 46 (9.2%) | 41 (8.8%) | 65 (13.9%) |
| ACE/ARB blocker | 295 (31.4%) | 57 (11.4%) | 49 (10.5%) | 69 (14.8%) |
| Beta blocker | 288 (30.7%) | 59 (11.8%) | 50 (10.7%) | 69 (14.8%) |
| Nitrates | 219 (23.3%) | 28 (5.6%) | 27 (5.8%) | 44 (9.4%) |
| Statins | 279 (29.7%) | 38 (7.6%) | 35 (7.5%) | 69 (14.8%) |
| Clinical findings | ||||
| Mean systolic BP, mm Hg (SD) | 145 (24.2) | 141 (21.5) | 140 (20.6) | 141 (21.8) |
| Mean diastolic BP, mm Hg (SD) | 85 (14.1) | 85 (13.9) | 85 (13.5) | 86 (13.4) |
| ECG showing signs of acute ischaemia | 63 (6.7%) | 3 (0.6%) | 3 (0.6%) | 0 |
| MACE within 30 days | ||||
| Final diagnosis of index visit myocardial infarction | 75 (8.0%) | 4 (0.8%) | 0 | 1 (0.2%) |
| Total MACE (including unstable angina) | 116 (12.4%) | 6 (1.2%) | 1 (0.2%) | 4 (0.9%) |
| All cause death within 30 days | 4 (0.4%) | 1 (0.2%) | 0 | 0 |
Values are mean (SD) or n (%).
*Defined as close relative with AMI, angina or cardiac death before the age of 55 years.
ACS, acute coronary syndrome; ADP, accelerated diagnostic protocol; ADP inhibitor, adenosine diphosphate receptor inhibitor; ARB blocker, angiotensin II receptor blocker; CABG, coronary artery bypass graft; MACE, major adverse cardiovascular events; PCI, percutaneous coronary intervention; TIA, transitory ischaemic attack.