Abstract 981 Table 1

Description of the studies included in the systemic review

StudyStudy typePatient groupOutcomesWeakness/comments
Dentali et al, Italy, 20123 A Systematic review and meta-analysis 1134 Patient with suspected or diagnosed CVT. D-dimer with CT or MRI venography was done for all patients. D-dimer elevated in 145/155 CVT patients, sensitivity 93.8%, and normal in 692/771 of non CVT patients, specificity 89.7% The included studies are of low quality with variable designs. Diffèrent reference tastes, variable d dimer assays and cut-off points.
Alons et al, Netherlands 20154 A Systematic review and Meta-analysis 636 patient with isolated headache & normal neurological exam. D-dimer & CT or MRI venography was done for all patient 45/636 CVT cases, One had a normal D-dimer. Sensitivity: 97.8%. Specificity: 84.9% Patients with normal neurological exam & CT brain with a negative D-dimer are less likely to have CVT, < 0.2%. The study looked for low risk patient, with isolated headache and normal neurological exam . high risk group with neurological symptomswas excluded, so the results can’t be generalized.
Six potential studies were excluded because of missing data about an isolated headache.
Thammishetti V. India, 20165 Prospective cohort study, 80 patients with CVTS confirmed or excluded by CT or MRI venography .
D-dimer was done in all patients
65/80 conformed CVT cases.
The D-dimer sensitivity and specificity was 80.62% & 80% respectively.
No statistical significant value for D-dimer between CVT and non CVT group during puerperal period.
No details about patients recruitments, with the possibility of selection bias.
The used D-dimer semiquantative latex test has less sensitivity than then-recent D-dimer assays.